Salivary gland cancers

Carcinomas of salivary glands click to access explanations in the original CAP template

** Please also refer to H&N biomarker protocol (HeadNeckBiomarkers 2.3.0.0, Apr-2026) for possible ancillary testings.

Microscopic descriptions:

- Tumor histology and immunohistochemical studies:

- Histologic type (WHO 5e):
- Grade/Intrinsic biologic potential:
- Macroscopic tumor extent:
- Lymphatic and/or Vascular Invasion:
- Perineural invasion:

## The following scenarios are not considered T category defining “bone invasion”:
1) Destruction of intrinsic sinus bone in sinonasal primaries;
2) Erosion of cortical bone;
3) Primary intraosseous (central) salivary gland tumors.

Surgical margins:

- Invasive Tumor:
- Tumor bed margin :

** Please also refer to additional specimens and frozen sections for margin status.

Lymph nodes examination :

- Number of regional lymph nodes examined :
- Number of lymph nodes involved :
- Extranodal extension (ENE) :
- Size of largest metastatic deposit (mm), specify site :
- Size of largest lymph node involved (mm), specify site :
- Laterality :

** Please include also intraparotid and periparotid lymph nodes, in addition to the lymph nodes of the neck dissections.

Distant Metastasis: Not applicable Not identified Non-regional lymph node(s) (specify): Lung (specify): Liver (specify): Bone (specify): Brain (specify): Other (specify): Cannot be determined:

Pathologic Stage Classification (AJCC 9e):

+ Modified classification:	r (recurrent) y (post-neoadjuvant therapy)
- Primary tumor (pT):
+ T-suffix:	m (multiple primary tumors)
- Regional lymph nodes (pN):
- Distant metastasis (pM):

pT0: No evidence of primary tumor
pTis: Carcinoma in situ
pT1: Tumor is less than or equal to 2 cm in greatest dimension without extraparenchymal extension#
pT2: Tumor is greater than 2 cm but less than or equal to 4 cm in greatest dimension withoutextraparenchymal extension#
pT3: Tumor is greater than 4 cm and / or gross extraparenchymal extension (for major salivary glands)#
pT4a: Tumor invades any immediately adjacent structures, including: skin, bone, cartilage, solid organ parenchyma, esophagus, trachea, named nerve##
pT4b: Tumor invades beyond any adjacent structures, including: encasement of carotid artery, base of skull invasion (except nasopharynx), spinal column invasion, intracranial invasion, orbital apex, prevertebral space, mediastinal structures, masticator space
pT4 (subcategory cannot be determined)

# Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues or nerve, except those listed under T4a and T4b. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.
## The following scenarios are not considered T category defining “bone invasion”: 1) Destruction of intrinsic sinus bone in sinonasal primaries; 2) Erosion of cortical bone; 3) Primary intraosseous (central) salivary gland tumors.

- Additional notes: